Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9359658 | The Spine Journal | 2005 | 9 Pages |
Abstract
This study supports the concept of a relationship between perineural fibrosis and radicular neuropathy in the model described, and emphasizes the role of disc injury and spinal nerve retraction in the post-laminectomy fibrotic process. Furthermore, it shows promise for preliminary assessment of interventions with other anti-inflammatory agents, for characterization of the neurochemical profile of the post-laminectomy pain state, and for exploration of newer pharmaceutical agents potentially useful in the prevention or management of the post-laminectomy syndrome. Post-laminectomy scar is but one of many potential causes of the post-laminectomy pain syndrome. Furthermore, a cautionary note must be emphasized as in all studies using preclinical models, conclusions drawn from the studies cannot be extended directly to patients without confirmatory clinical follow-up studies.
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Authors
Jennifer B. MS, Aimee L. MD, Bill MD, Choll W. MD, PhD, Steven R. MD, Wayne H. MD,