Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
936674 | Neurobiology of Learning and Memory | 2012 | 6 Pages |
To investigate whether de novo protein synthesis in the parabrachial nucleus (PBN) is required for recovery from taste neophobia, anisomycin (a protein synthesis inhibitor) was infused immediately after consumption of a novel saccharin solution (Experiment 1). Unexpectedly, this PBN treatment caused a reduction in saccharin intake. In addition, we found that the anisomycin-induced suppression of tastant intake was attenuated by prior intra-PBN infusions of lidocaine (Experiment 2). This pattern of results raises concerns about using anisomycin to investigate memory consolidation processes in the PBN. Thus, a different manipulation may be needed to examine the nature of the neuroplastic changes that occur in the PBN during taste memory formation.
► We examined the effect of intra-PBN infusions of anisomycin on taste neophobia. ► Contrary to expectations, anisomycin suppressed intake of the saccharin tastant. ► Pre-treatment with lidocaine attenuated the taste suppressing effect of anisomycin.