Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9366912 | Pathologie Biologie | 2005 | 4 Pages |
Abstract
Thirty-seven patients operated from a Dukes B2-C colon cancer were randomised to receive as adjuvant infusional chemotherapy, nine 5 FU and folinic acid courses with or without carboplatin, as standard (de Gramont ; 2 days every 2 weeks) or chronomodulated administration (4 days every 2 weeks). The overall tolerance was judged excellent with less than 7% courses with dose-adaptations. The two carboplatin arms presented an enhanced haematological toxicity, while some more cutaneous toxicity was observed in the chronomodulated arm with the three drugs.
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Authors
C. Focan, J. Bury, G. Matus, M.P. Graas, F. Kreutz, L. Longree, N. Moeneclaey, A. David, D. Focan-Henrard,