| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9367376 | Pathophysiology | 2005 | 5 Pages |
Abstract
Wistar rats were allowed to self-administer morphine (1Â mg/infusion) during 10 consecutive days for 2Â h/session. The number of lever pressings was recorded. An intrapritoneal AA injection (500Â mg/kg, i.p.), 30Â min before morphine self-administration produced a significant decrease in the initiation of morphine self administration during all sessions. After the last test session morphine withdrawal symptom signs (MWS) were recorded after naloxone precipitation. Most of MWS (but not all) were decreased by AA application. In conclusion, AA may change the motivational processes underlying the morphine self-administration.
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Authors
H. Alaei, M. Esmaeili, A. Nasimi, A. Pourshanazari,