Contractility of rat gubernacula affected by calcitonin gene-related peptide and β-agonist

Although the β-blocker showed a weak inhibitory effect on de novo gubernacular contractility, CGRP had a stronger effect on contractility, overriding any possible effects of the β-neuron pathway. The contractility of the rat gubernaculum during testicular descent is primarily mediated by the genitofemoral sensory nerve fibers via release of CGRP, but β-adrenergic nerves also may be involved.