Article ID Journal Published Year Pages File Type
9373723 Journal of Pediatric Surgery 2005 7 Pages PDF
Abstract
The absence of embryonic expression of Fgf10 or its receptor Fgfr2b results in colonic atresia in mice. India ink microinjection is a direct measure of mesenteric arterial patency. Colonic atresia in the Fgf10−/− and Fgfr2b−/− mutants occurs despite normal mesenteric vascular development. Thus the atresia is not the result of a mesenteric vascular occlusion. The patent colonic mesentery of the Fgf10−/− and Fgfr2b−/− mutants challenges an accepted pathogenesis of intestinal atresia. Although colonic atresia can occur as a result of vascular occlusion, new evidence exists to suggest that a genetic mechanism may play a role in the pathogenesis of this disease.
Related Topics
Health Sciences Medicine and Dentistry Perinatology, Pediatrics and Child Health
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