Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9373723 | Journal of Pediatric Surgery | 2005 | 7 Pages |
Abstract
The absence of embryonic expression of Fgf10 or its receptor Fgfr2b results in colonic atresia in mice. India ink microinjection is a direct measure of mesenteric arterial patency. Colonic atresia in the Fgf10â/â and Fgfr2bâ/â mutants occurs despite normal mesenteric vascular development. Thus the atresia is not the result of a mesenteric vascular occlusion. The patent colonic mesentery of the Fgf10â/â and Fgfr2bâ/â mutants challenges an accepted pathogenesis of intestinal atresia. Although colonic atresia can occur as a result of vascular occlusion, new evidence exists to suggest that a genetic mechanism may play a role in the pathogenesis of this disease.
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Authors
Timothy J. Fairbanks, Robert C. Kanard, Pierre M. Del Moral, Fred G. Sala, Stijn P. De Langhe, Chrissy A. Lopez, Jacqueline M. Veltmaat, David Warburton, Kathryn D. Anderson, Saverio Bellusci, R. Cartland Burns,