| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9377433 | Biological Psychiatry | 2005 | 7 Pages |
Abstract
Mania is associated with a significant attenuation of task-related activation of right lateral orbitofrontal function. This lack of activation of a brain region that is usually involved in suppression of responses might account for some of the disinhibition seen in mania. In addition, hippocampal and cingulate activation seem to be decreased. The relationship between this reduced function and the symptoms of mania remain to be further explored.
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Authors
Lori L. Altshuler, Susan Y. Bookheimer, Jennifer Townsend, Manuel A. Proenza, Naomi Eisenberger, Fred Sabb, Jim Mintz, Mark S. Cohen,