Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9377533 | Biological Psychiatry | 2005 | 10 Pages |
Abstract
In elderly subjects with depression, the density of pyramidal neurons in the ORB was particularly low in cortical layers V and III, the origin of prefronto-striatal and prefronto-cortical and prefronto-amygdalar projections. Degeneration of neurons furnishing these projections might be related to the white matter hyperintensities previously observed. Neuronal pathology seems to be more severe in elderly than in younger subjects with MDD.
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Authors
Grazyna Rajkowska, Jose Javier Miguel-Hidalgo, Priti Dubey, Craig A. Stockmeier, K. Ranga Rama Krishnan,