Article ID Journal Published Year Pages File Type
9377773 Biological Psychiatry 2005 7 Pages PDF
Abstract
The relatively low potency of radafaxine in blocking DAT and its slow blockade suggests that it is unlikely to have reinforcing effects. This is consistent with preclinical studies showing no self-administration. This is the first utilization of PET to predict abuse liability of a new antidepressant in humans based on DAT occupancy and pharmacokinetics.
Related Topics
Life Sciences Neuroscience Biological Psychiatry
Authors
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