Effets secondaires psychiatriques des médicaments non psychotropes

Many drugs, from various therapeutic classes, may induce side-effects of possible psychiatric origin. Awareness of such effects is paramount in terms of therapy and prognosis. The problem of imputability when the drug itself is a psychotropic compound raises complex issues; in other cases, when the suspected drug is not a psychotropic compound, causality is easier to substantiate. Authors try to review psychiatric side-effects of non psychotropic drugs. Results are presented in tables following algorithms of the Vidal TM physician desk reference dictionary, in order to remain closer to daily practice, in psychiatry or other specialties. The most frequently reported side-effect is clouding of consciousness (confusion, delirium), but phenomenological descriptions often remain vague. Information defining circumstances or risk factors for side-effects are given as often as possible. Data presented here originate from 3 different reference books and a recent literature search. General considerations on imputability and specific methodological problems are beyond the scope of this review.