Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9385844 | Respiratory Medicine | 2005 | 9 Pages |
Abstract
Conclusions: We found that 3 months of treatment with fluticasone propionate and salmeterol reduced airway hyperresponsiveness, FENO and tryptase density in the airway mucosa as markers of airway inflammation. MBP density in the airway mucosa and QOL were, however, unchanged. The clinical relevance of these findings, especially with respect to the long-term outcome, has not been determined yet.
Keywords
LABAsSFCAMPReticular basement membraneMBPPD20QOLBALFluticasoneFeNOMCHQuality of lifeadenosine-5′-monophosphateAsthmaLong-acting β2-agonistsEosinophilsinflammationRemissionexhaled nitric oxideRemodelingSalmeterolRBMbronchoalveolar lavageMast cellsMethacholineBronchial Hyperresponsivenessmajor basic protein
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Authors
Leon M. van den Toorn, Jan-Bas Prins, Johan C. de Jongste, Karolina Leman, Paul G.H. Mulder, Henk C. Hoogsteden, Shelley E. Overbeek,