Immunomonitoring of Renal Transplant Recipients in the Early Posttransplant Period by Sequential Analysis of Chemokine and Chemokine Receptor Gene Expression in Peripheral Blood Mononuclear Cells

We have demonstrated that changes in chemokine receptor/ligand gene expression by sequential monitoring in PBMCs can be detected in the early posttransplant period. In particular, CCR1 and CXCL10, which showed increased expression prior to rejection and returned to baseline levels with antirejection therapy, may have potential use in immunomonitoring and as predictive factors of rejection prior to its clinical manifestation.