Relative Adrenal Insufficiency Among Trauma Patients in a Community Hospital

Relative adrenal insufficiency after trauma is rare. In RAI, clear signs and symptoms are usually absent. The clinical diagnostic clue may be the unexplained hypotension and the resistance to inappropriately high doses of inotropes and vasoactive agents. The hemodynamic profile often shows a hyperdynamic state of high cardiac output and a low systemic vascular resistance. Baseline serum cortisol levels did not correlate with injury severity scores in this group of patients, which suggests a defect in the HPA axis. An intensive care unit day stay of greater than or equal to 20 days, ventilator dependence/acute respiratory distress syndrome, and a hyperdynamic state mandates consideration of endocrine testing to exclude RAI. Physiologic doses of hydrocortisone can reverse this potentially life-threatening syndrome.