Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9401488 | Journal of Gastrointestinal Surgery | 2005 | 10 Pages |
Abstract
Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.
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Authors
Susanna L. M.D., Charles J. M.D., Ralph H. M.D., Michael A. M.D.,