Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9402323 | Journal of Surgical Research | 2005 | 9 Pages |
Abstract
A fully autologous human model consisting of tumor cells as stimulator cells and tumor-draining lymph nodes as responder cells can be used to test immunotherapeutic strategies. T cells in these lymph nodes are unresponsive to autologous tumor cells, but this lack of responsiveness can be reversed in the presence of GM-CSF and CD40L. These data provide a rationale for testing tumor cell vaccines incorporating GM-CSF- and CD40L-expressing bystanders in clinical trials.
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Authors
Sophie M.D., Ph.D., Marwan M.Sc., Susan M.Sc., Terri Ph.D., David B.Sc., David B.Sc., Jennifer B.Sc., John M.D., Ron B.Sc., Scott J. M.D., Ph.D.,