Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9402434 | Journal of Surgical Research | 2005 | 8 Pages |
Abstract
VEGF has been shown to up-regulate a number of survival signals in endothelial cells. We have found that exposure of human neuroblastoma cells to exogenous VEGF results in an increased expression of survivin protein and phosphorylated Akt, and inhibition of PI3-kinase abrogates those effects. It appears that VEGF is important for promotion of neuroblastoma cellular survival through the up-regulation of survival proteins, and not only through its angiogenic properties.
Keywords
Related Topics
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Medicine and Dentistry
Surgery
Authors
Elizabeth A. M.D., Abhilasha M.S., Wei M.D., Meera B.S., Mike K. M.D.,