Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9402482 | Journal of Surgical Research | 2005 | 6 Pages |
Abstract
This study demonstrates that the aorta exposed to endotoxin releases a substance that vasodilates resistance arterioles through the up-regulation of iNOS. Aminoguanidine prevented the fall in tone following exposure to endotoxin, while use of the nonselective NOS inhibitor, l-NAME, not only blocked the fall due to endotoxin but increased basal tone by blocking the constitutively active eNOS.
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Authors
Anthony W. M.D., Russell L. Ph.D., F.A.H.A., Michael Ph.D., L.D. M.D., M.P.H.,