Differential Expression of Immunoglobulin Kappa Chain Constant Region in Human Abdominal Aortic Aneurysm

Our finding suggests that differentially expressed Ig κ-C gene only in AAA is a candidate gene that may play a pivotal role in the pathogenesis of AAA formation. The correlation of mRNA level and protein level is, however, not clear. Thus, to directly identify the role of Ig light chains in the pathogenic event of AAA, the further study comparing the level and kinds of expressed protein with the corresponding Ig κ-C gene will be required.