Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9404479 | Surgery | 2005 | 8 Pages |
Abstract
CDX2 mRNA and CDX2 protein expression are upregulated in Barrett's IM tissues, compared with normal squamous esophagus, and remain elevated in dysplasia and adenocarcinoma tissues. In contrast, PITX1 mRNA expression is decreased in Barrett's esophagus, compared with matching normal squamous esophagus specimens, and is further decreased in Barrett's-associated cancer. These descriptive findings suggest a possible role for these genes in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.
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Authors
Reginald V.N. MD, Jan MD, Kumari MD, Steven R. MD, Arnulf MD, Paul M. MD, Peter V. PhD, Tom R. MD,