| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9404691 | Surgery | 2005 | 8 Pages |
Abstract
Manumycin inhibits cell proliferation and decreases PTHrP levels in anaplastic thyroid cancer cells in vitro and in vivo and decreases the PTHrP level in the nucleus where PTHrP may function as an oncoprotein. These data suggest that PTHrP has a novel role in anaplastic thyroid cancer and that modulation of PTHrP levels may be of therapeutic benefit in this lethal malignancy.
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Authors
Alan MD, PhD, Jingxuan MD, Phd, Guangpu MD, Phd, Sai-Ching J. MD,