| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9404823 | Surgery | 2005 | 8 Pages |
Abstract
Cholestatic injury results in increased fibrosis, MNPs, KCs, and PMNs but no MMP-2 or MMP-8 activity. Biliary decompression results in increased MMP-8 activity co-localized to areas of portal fibrosis and PMN accumulation. We conclude that secretion of MMP-8 by neutrophils may play a critical role in resolving the fibrotic scar generated during cholestasis.
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Authors
Mark W. PhD, Hannah M. MD, Elaine F. BS, Tauquir Puthawala, Aaron P. Tracy, Grant A. PhD, Stephan MD, Stephen H. PhD, Thomas F. MD,