| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9404833 | Surgery | 2005 | 7 Pages |
Abstract
Inhibition of PI3K/Akt by RNA interference sensitizes resistant colon cancer cells to TRAIL-induced cell death through the induction of TRAIL receptors and activation of caspase-3 and caspase-8. Agents that selectively target the PI3K/Akt pathway may enhance the effects of chemotherapeutic agents and provide novel adjuvant treatment for selected colon cancers.
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Authors
Piotr G. MD, Carlos A. MD, B. Mark MD,