| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9405034 | Surgery | 2005 | 7 Pages |
Abstract
Pancreatic cancer cells are resistant to TRAIL-induced apoptosis via strong expression of the anti-apoptotic protein FLIP-S. Suppression of FLIP-S by cycloheximide restored sensitivity to TRAIL-induced apoptosis in resistant cancer cells. These findings may provide useful information for the development of TRAIL-based therapeutic strategies aimed at restoring the functionality of apoptotic pathways in pancreatic cancer cells.
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Authors
Tomohiko MD, Ryuichiro MD, Eiji MD, Masayuki MD, Daisuke MD, Kazuhiro MD, Atsushi MD, Toshihiko MD, Yoshiya MD, Koji MD,