Article ID Journal Published Year Pages File Type
9406476 Behavioural Brain Research 2005 12 Pages PDF
Abstract
At all ages, Tg mice showed normal short-term memory in the Y-maze. Pre-plaque Tg and age-matched Non-Tg mice did not differ in learning the spatial Morris water maze. However, both early and late plaque Tg mice showed impairments during acquisition. In addition, although early plaque Tg mice performed well in the probe trial, late plaque Tg mice demonstrated impaired probe trial performance. Therefore compared to their Non-Tg littermates, Tg CRND8 mice demonstrate cognitive impairments that progressed with age and seemed to coincide with the onset of β-amyloid plaque deposition.
Related Topics
Life Sciences Neuroscience Behavioral Neuroscience
Authors
, , , , , , , , , , ,