α2-Adrenergic agonists antagonise the anxiolytic-like effect of antidepressants in the four-plate test in mice

The results of this present study indicate that α2-adrenoceptor agonists antagonise the anxiolytic-like effect of antidepressants in mice when they are administered 15 min before the administration of antidepressant suggesting a close inter-regulation between noradrenergic and serotoninergic system in the mechanism of SSRIs and SNRIs in anxiety-like behaviour.