Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9406569 | Behavioural Brain Research | 2005 | 6 Pages |
Abstract
Despite the well-described attention and short-term memory enhancing effects of H3 receptor antagonists, and evidence to suggest a close relationship between central histaminergic and cholinergic systems, there is a paucity of evidence for a role for H3 receptor blockade in spatial learning. To address this, we investigated two H3 receptor antagonists in a visual discrimination water maze in rats, and in a Barnes circular maze in mice. Thioperamide and ciproxifan significantly attenuated a scopolamine-induced deficit in the water maze task, while only ciproxifan showed a modest attenuation in the Barnes maze. Taken together, these data suggest a role for H3 receptors in spatial learning that appears to be task-dependent.
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Authors
Victoria A. Komater, Michael J. Buckley, Kaitlin E. Browman, Jia Bao Pan, Arthur A. Hancock, Michael W. Decker, Gerard B. Fox,