Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9406588 | Behavioural Brain Research | 2005 | 8 Pages |
Abstract
The aim of this work was to study effects of mild preconditioning hypobaric hypoxia (380Â Torr for 2Â h, repeated 3 or 6 times spaced at 24Â h) on brain NGFI-A immunoreactivity and passive avoidance (PA) behavior in rats exposed to severe hypoxia (160Â Torr for 3Â h). Severe hypobaric hypoxia produced extensive neuronal loss in hippocampal CA1, while the preceding hypoxic preconditioning had clear protective effect on neuronal viability of vulnerable hippocampal cells. Besides, the hypoxic preconditioning prevented impairment of acquisition and retention of PA caused by severe hypoxia. The six-trial hypobaric preconditioning was more effective in protection against PA learning deficits in severe hypoxia exposed rats than the three-trial preconditioning. The preconditioning up-regulated severe hypoxia-suppressed neocortical and hippocampal expression of NGFI-A, suggesting a possible role for NGFI-A in the neuroprotective mechanisms activated by hypoxic preconditioning.
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Authors
Elena Rybnikova, Ludmila Vataeva, Ekaterina Tyulkova, Tatiana Gluschenko, Vladimir Otellin, Markku Pelto-Huikko, Michail O. Samoilov,