Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9406594 | Behavioural Brain Research | 2005 | 8 Pages |
Abstract
The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H1 and H2 antagonists having been found to potentiate conditioned place preference induced by morphine or cocaine. In contrast, the role of H3 receptors in cocaine-induced place preference is still unknown. The present study tested the effects of thioperamide (0, 10 and 20Â mg/kg, i.p.), an H3 autoreceptor antagonist, on the development of a conditioned place preference induced by cocaine (0, 2 and 8Â mg/kg, i.p.) in C57BL/6J mice. Thioperamide was injected 10Â min before each cocaine-pairing session. The activity scores recorded on the first cocaine-pairing session were also used to test the effects of thioperamide on cocaine-induced locomotor activity. Thioperamide alone had no reinforcing effects and did not affect the conditioned place preference induced by 8Â mg/kg cocaine. However, thioperamide dose-dependently revealed a conditioned place preference induced by 2Â mg/kg cocaine, a dose that was inactive per se. Finally, thioperamide dose-dependently potentiated the stimulant effects of cocaine, in spite of its slight hypolocomotor effect when given alone. Our results strongly suggest that H3 antagonists potentiate the stimulant and reinforcing effects of cocaine in mice.
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Authors
Christian Brabant, Yana Charlier, Etienne Quertemont, Ezio Tirelli,