Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9409586 | Brain Research Bulletin | 2005 | 7 Pages |
Abstract
Following infraorbital nerve transection, underlying mechanisms of the altered synaptic strength were studied in rat barrel cortex slice experiments. In addition to the in vitro electrophysiological studies, open-field tests were run to detect possible behavioural changes associated with cortical oversensitization. Enhanced NMDA receptor-mediated component of the evoked field response appeared in the barrel cortex after nerve injury. The alteration was transient, very distinct on the first day following injury, and almost returned to normal level by the end of the second week. Behavioural changes had not followed this time-course since long-lasting alterations were detected in the open-field test. These observations are in agreement with findings that showed biphasic regenerative processes following nerve injuries in other cortical areas.
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Authors
I. Világi, G. Bárdos, K. Dénes, B. Farkas, P. Friedrich,