Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9410562 | Molecular Brain Research | 2005 | 8 Pages |
Abstract
Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes. The number of MAP-, PCP-, and MAP and PCP-reactive tags were 229, 215, and 41, respectively.
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Authors
Yuta Ouchi, Yasuhiko Kubota, Atsuo Kuramasu, Takehiko Watanabe, Chihiro Ito,