Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice

We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons.