Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9410823 | Molecular Brain Research | 2005 | 4 Pages |
Abstract
We investigated three genotypes (AA, AT, and TT) produced by signal peptide polymorphism of the α-1-antichymotrypsin (ACT) gene in 105 patients with multiple system atrophy (MSA) and age-matched controls. The frequency of ACT-AA genotype was significantly higher in patients with MSA (20.0%) than in controls (10.5%). The onset of MSA was significantly earlier and the disease progressed significantly faster in patients with ACT-AA genotype than in those with non-ACT-AA genotypes. The ACT concentration in cerebrospinal fluid was increased in patients with ACT-AA. To our knowledge, this is the first study to show that the ACT-AA genotype is a risk factor and modulating factor for MSA. Our findings suggest the involvement of ACT-relating inflammatory process in the pathogenesis of MSA.
Keywords
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Yoshiko Furiya, Makito Hirano, Norio Kurumatani, Takuya Nakamuro, Ryusuke Matsumura, Naonobu Futamura, Satoshi Ueno,