Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9414569 | Developmental Brain Research | 2005 | 7 Pages |
Abstract
Thereafter, the relationships between TRH and the hypothalamus-pituitary-adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T3 and T4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus-pituitary-adrenal axis rather than the hypothalamus-pituitary-thyroid axis.
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Authors
Hirokazu Takahashi, Masayuki Iigo, Kôichi Ando, Tetsuya Tachibana, D. Michael Denbow, Mitsuhiro Furuse,