Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9414575 | Developmental Brain Research | 2005 | 4 Pages |
Abstract
An epigenetic key protein MeCP2 is thought to be expressed exclusively in mature neurons. Here, we show that MeCP2 is expressed in embryonic non-neuronal cells by immunocytochemistry and Western blotting, and that knockdown of MeCP2 levels using RNA interference reduces their proliferation. These findings suggest that MeCP2 is essential to non-neuronal cell growth during brain development, which may be associated with microcephaly of Rett syndrome patients with MeCP2 mutations.
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Neuroscience
Developmental Neuroscience
Authors
Kaoru Nagai, Kunio Miyake, Takeo Kubota,