Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9414750 | Developmental Brain Research | 2005 | 5 Pages |
Abstract
Thyroid hormones (THs) are important for brain development, and polychlorinated biphenyl (PCB) accumulation in humans is a serious problem because PCBs may affect TH functions. To determine the effects of hydroxylated metabolites of PCBs (OH-PCBs) on brain development, we performed mouse cerebellar culture assays. 4-OH-2â²,3,3â²,4â²,5â²-pentachlorobiphenyl and 4-OH-2â²,3,3â²,4â²,5,5â²-hexachlorobiphenyl significantly inhibited the TH-dependent extension of Purkinje cell dendrites even at 5 Ã 10â11 M and 5 Ã 10â12 M, respectively. OH-PCBs may disturb TH-dependent brain development.
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Authors
Junko Kimura-Kuroda, Isao Nagata, Yoichiro Kuroda,