Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9415663 | Brain Research | 2005 | 5 Pages |
Abstract
We investigated the effects of an Na+/H+ exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca2+]i. In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.
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Authors
Hye-Seong Park, Bo Kyung Lee, Sok Park, Seung U. Kim, Soo Hwan Lee, Eun Joo Baik, Sunkyung Lee, Kyu Yang Yi, Sung Eun Yoo, Chang-Hyun Moon, Yi-Sook Jung,