Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9415820 | Brain Research | 2005 | 4 Pages |
Abstract
Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.
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Authors
Nicola Berretta, Michela Giustizieri, Giorgio Bernardi, Nicola B. Mercuri,