Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9415831 | Brain Research | 2005 | 4 Pages |
Abstract
Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10â8 M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.
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Authors
Gerald A. Marks, Christian G. Birabil, Samuel G. Speciale,