Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9415894 | Brain Research | 2005 | 10 Pages |
Abstract
Taken together with the known neurochemistry and neuronal distribution of the Asc-1 transporter, these results indicate that the mechanism underlying the behavioral hyperexcitability in mutant mice is likely due to overactivation of NMDA receptors, presumably resulting from elevated extracellular d-serine. Our study provides the first evidence to support the notion that Asc-1 transporter plays a critical role in regulating neuronal excitability, and indicate that the transporter is vital for normal CNS function and essential to postnatal survival of mice.
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Authors
Xinmin Xie, Theodore Dumas, Lamont Tang, Thomas Brennan, Thadd Reeder, Winston Thomas, Robert D. Klein, Judith Flores, Bruce F. O'Hara, H. Craig Heller, Paul Franken,