Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9415925 | Brain Research | 2005 | 5 Pages |
Abstract
We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses.
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Authors
Kin-ya Kubo, Fumihiko Iwaku, Kazuko Watanabe, Masafumi Fujita, Minoru Onozuka,