| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9416220 | Brain Research | 2005 | 6 Pages |
Abstract
Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.
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Neuroscience
Neuroscience (General)
Authors
Rui-Xin Zhang, Linbo Wang, Bing Liu, Jian-Tian Qiao, Ke Ren, Brian M. Berman, Lixing Lao,