Article ID Journal Published Year Pages File Type
9416244 Brain Research 2005 4 Pages PDF
Abstract
Female rats demonstrate higher pain sensitivity than do males in various nociceptive assays of inflammation. In the present study, we found that estradiol (20%) replacement in ovariectomized rats attenuated the chronic phase of the formalin response but only at high formalin concentrations thought to rely on peripheral inflammation. An inactive isomer of estradiol, α-estradiol, failed to result in the same attenuation (P > 0.05). Our results suggest that estradiol's actions in inflammatory responses are mediated through genomic estrogen receptor-mediated mechanisms.
Related Topics
Life Sciences Neuroscience Neuroscience (General)
Authors
, , ,