Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9416244 | Brain Research | 2005 | 4 Pages |
Abstract
Female rats demonstrate higher pain sensitivity than do males in various nociceptive assays of inflammation. In the present study, we found that estradiol (20%) replacement in ovariectomized rats attenuated the chronic phase of the formalin response but only at high formalin concentrations thought to rely on peripheral inflammation. An inactive isomer of estradiol, α-estradiol, failed to result in the same attenuation (P > 0.05). Our results suggest that estradiol's actions in inflammatory responses are mediated through genomic estrogen receptor-mediated mechanisms.
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Authors
Tzipora Kuba, Lynne M. Kemen, Vanya Quinones-Jenab,