Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9416302 | Brain Research | 2005 | 5 Pages |
Abstract
We examined the ultrastructural localization of oligomeric proteins, Aβ42, and flotillin-1 in Tg2576 mouse brains by triple immunoelectron microscopy. Oligomer-specific immunoreactions localized to cell processes, especially to axon terminals with higher density in Tg than in nonTg mouse brains. The oligomer was less frequently colocalized to flotillin-1-immunoreactive rafts than Aβ42, suggesting that rafts are one of the sites of polymeric Aβ deposition, but not of oligomeric proteins including Aβ.
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Authors
Hideko Kokubo, Rakez Kayed, Charles G. Glabe, Takaomi C. Saido, Nobuhisa Iwata, J. Bernd Helms, Haruyasu Yamaguchi,