Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9416352 | Brain Research | 2005 | 8 Pages |
Abstract
We observed that chronic administration of melatonin significantly reduced the lipid peroxidation and restored the decreased glutathione levels induced by chronic hyperhomocysteinemia. Chronic hyperhomocysteinemia significantly impaired learning and memory performance in the passive avoidance test and Morris water maze task. We also found that these cognitive deficits were reversed by chronic treatment with antioxidant melatonin. Furthermore, melatonin administration was able to modulate the expression pattern of neural cell adhesion molecules in hippocampus. The results provide evidence that homocysteine induces long-lasting behavioral deficits, which are possibly caused by oxygen reactive species generation, and by changing in synaptic plasticity and also suggest that melatonin treatment has the ability to prevent nervous system against homocysteine toxicity.
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Neuroscience (General)
Authors
Giyasettin Baydas, Mehmet Ãzer, Abdullah Yasar, Mehmet Tuzcu, Sema T. Koz,