Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9416405 | Brain Research | 2005 | 5 Pages |
Abstract
The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have shown that the effects of peripheral administration of both peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurones are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY3-36 and GLP-1 on food intake.
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Authors
Caroline R. Abbott, Mariana Monteiro, Caroline J. Small, Arshia Sajedi, Kirsty L. Smith, James R.C. Parkinson, Mohammad A. Ghatei, Stephen R. Bloom,