| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9416458 | Brain Research | 2005 | 8 Pages |
Abstract
This is the first report of experimentally induced in vivo accumulation of α-synuclein in non-transgenic rodent brain injected with a well-characterized protease inhibitor by an infusion pump. The present finding suggests that the local accumulation of α-synuclein might be induced by the impaired metabolism of α-synuclein, which are likely related to lysosomal or ubiquitin-independent proteasomal systems.
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Authors
T. Nakajima, S. Takauchi, K. Ohara, M. Kokai, R. Nishii, S. Maeda, A. Takanaga, T. Tanaka, M. Takeda, M. Seki, Y. Morita,