Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9416485 | Brain Research | 2005 | 10 Pages |
Abstract
TPH-IR, an index of the amount of TPH enzyme, in the DRN is higher in depressed suicides. More TPH may be an upregulatory homeostatic response to impaired serotonin release or less autoreceptor activation. Alternatively, the serotonin impairment in suicide may be due to hypofunctional serotonin-synthesizing enzyme.
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Authors
Maura Boldrini, Mark D. Underwood, J. John Mann, Victoria Arango,