| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9416513 | Brain Research | 2005 | 5 Pages |
Abstract
We evaluated the expression of DNA repair proteins, redox factor-1 (Ref-1) and X-ray repair cross-complementing protein 1 (XRCC1), relevant to neurodegeneration following kainic acid-induced seizures in rats. Neurons with oxidative DNA damage exhibited increased expression and colocalization of Ref-1 and XRCC1. Upregulation of DNA repair proteins was also associated with p53 induction and TUNEL. Coexpression of DNA repair proteins and cell death markers following seizures suggests that the DNA repair response may not be sufficient to prevent excitotoxin-induced neurodegeneration.
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Authors
Nancy Quach, Tony Chan, Tony Au Lu, Steven S. Schreiber, Zhiqun Tan,