Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9416879 | Brain Research | 2005 | 6 Pages |
Abstract
The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAOâ/â mice lacking d-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the d-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated d-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia.
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Authors
Atsushi Hashimoto, Masanobu Yoshikawa, Akira Niwa, Ryuichi Konno,