Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9422675 | Brain Research Protocols | 2005 | 10 Pages |
Abstract
We designed a three-trial “what”,-“where”-and-“when” object exploration task in which different versions of the novelty preference paradigm were combined to subsume (a) object recognition memory, (b) the memory for locations in which objects were explored and (c) the temporal order memory for objects presented at distinct time points. Our results suggest that mice are able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered and (c) discriminate the relative recency in which different objects were presented. We suggest that our protocol providing the simultaneous assessment of object memory for “what”,-“where”-and-“when” in mice might be useful in the search for the neural substrates of episodic memory, the screening for promnestic drugs and the behavioral phenotyping of genetic models of neuropsychiatric diseases affecting episodic memory.
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Authors
Ekrem Dere, Joseph P. Huston, Maria A. De Souza Silva,